IndraLab

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EGF leads to the phosphorylation of MAPK1 on tyrosine. 2 / 2
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"EGF, in a concentration- and time dependent manner, increases tyrosine phosphorylation and MBP kinase activity (i.e. activation) of ERK2, and to a lesser degree ERK1, suggesting that the activation of MAP kinase may mediate the mitogenic action of EGF in pGCs."

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"EGF stimulated tyrosine phosphorylation of ERK2, and MK-678 attenuated this effect."