IndraLab

Statements

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"Specifically, cAMP actives PKA, negatively regulates NF-KB pathway, thus suppressing the release of proinflammatory mediators (eg, TNF-alpha, interleukin-17, Interferon-gamma) XREF_BIBR."
25549252
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"Interestingly, PGE2 or di-butyryl (Bt2) cAMP abolished the binding of NF-kappa B (p50 and p65) heterodimer to the kappa B sequence in cells stimulated with anti-CD3 mAb but not with PMA and A23187."
8018594
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"However, NF-KB activation in human promyelocytic HL 60 cells by TNF-a or -treatment was independent of intracellular cAMP levels (Hohmann et al., 1991) and inhibition or down regulation of classical p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7584622
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"CAMP and NF-KB Elevated levels of cAMP are known to inhibit acti- vation of NF-KB (Refs 77-79; Fig. 3)."
8579753
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"In CD4 + T-cells, CGRP induces elevation of cellular cAMP levels and inhibits production of TNF-alpha, IFN-gamma, and NFkB."
29690884