IndraLab

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OTUB2 increases the amount of CD274. 5 / 5
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"Genetic deletion of OTUB2 markedly decreases the expression of PD-L1 proteins on the tumor cell surface, resulting in increased tumor cell sensitivity to CD8 + T-cell-mediated cytotoxicity."
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"On the structural basis of the binding pocket of OTUB2, we identify OTUB2-IN-1, a specific inhibitor of OTUB2, which can reduce the expression of PD-L1 proteins in tumor cells and suppress tumor growth by promoting robust intra-tumoral infiltration of CTLs."
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"In contrast, OTUB2 OE in lung cancer cells enhanced both endogenous PD-L1 expression and IFN-γ-induced PD-L1 expression (Fig. 3d−f and Supplementary Fig. 9a, b)."
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"Consistently, introduction of OTUB2-WT but not OTUB2-C51S enhanced both endogenous PD-L1 expression and IFN-γ-induced PD-L1 expression (Fig. 3d−f and Supplementary Fig. 9a, b)."
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"In this study, we found that OTUB2 inhibition may also inhibit cancer progression by suppressing Hippo signaling, AKT/mTOR signaling and NF-κB signaling in addition to the reduction of PD-L1 expression."
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