IndraLab

Statements

USP3 inhibits TRAF6. 3 / 3
| 3
reach
"Collectively, our results suggest that although USP3 could moderately reduce TRAF6‐induced NF‐κB activation (Zhou et al, 2019), it specifically inhibits TLR‐ and IL‐1β‐induced NF‐κB activation, mainly through the adaptor molecule MyD88.We next sought to determine whether USP3 could interact with MyD88."
37971847
reach
"For example, USP3 was deficient in OA and USP3 abundance suppressed IL-1β-induced chondrocyte apoptosis by targeting TRAF6 [6]."
37814350
reach
"To identify the molecular target of USP3, we co‐transfected USP3 with different signaling proteins in the NF‐κB pathway and found that USP3 mainly inhibited MyD88‐induced NF‐κB activation and slightly but significantly inhibited TRAF6‐induced NF‐κB activity only at a high USP3 concentration (Fig 3A)."
37971847