IndraLab

Statements

BetA1 activates KCNMA1. 4 / 4
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"20 These data suggested that beta1 competes with LRRC26 to modulate BK channel activity."
24906643
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"The increase in surface beta1 enhanced BK channel apparent Ca 2+ sensitivity and functional BK channel activity in pressurized arteries."
28487419
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"Results underscore that microM Ca 2+ i levels, while not necessary (XREF_FIG and XREF_SUPPLEMENTARY), are optimal for beta1 modulation of slo1, this modulation resulting in increased apparent Ca 2+ sensitivity and thus enhanced steady-state current XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR."
25275635
reach
"The guanylate kinase domain of Ca (v) beta1 mediates Slo1 regulation through its binding to calcium bowl domains, and this domain of Ca (v) beta1 is necessary and sufficient for the observed effects on BK (Ca) activation."
17989350