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IC 50 inhibits KCNH2. 2 / 2
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"The selective dopamine reuptake inhibitor GBR 12909 dihydrochloride (Vanoxerine) was the most potent compound, with an IC 50 In the literature, all of these drugs are reported to cause hERG inhibition [51] [52] [53] ."
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"Such noncardiovascular drugs included antipsychotics which block HERG with different degree of block : the concentrations required to produce 50% block of HERG (IC 50) were in nanomolar range for sert[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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