IndraLab

Statements

PPP3 dephosphorylates KCNK18. 8 / 8
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"Increased [Ca ] activates calcineurin, a calcium-activated serine–threonine phosphatase, and the calcineurin dephosphorylates TRESK to activate it."
29973548
sparser
"Increased [Ca 2+ ] i activates calcineurin, a calcium-activated serine–threonine phosphatase, and the calcineurin dephosphorylates TRESK to activate it."
29973548
sparser
"The calcineurin-dependent dephosphorylation and activation of TRESK in response to the calcium signal exerts a hyperpolarizing/repolarizing (or stabilizing) effect on the (resting) membrane potential [ xref , xref , xref , xref , xref ]."
39201565
sparser
"TREK-2 phosphorylated by PKC shows low channel activity [ xref ], whereas TRESK dephosphorylated by calcineurin shows high channel activity [ xref ]."
27382354
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"The coexpression of PKC slowed down the recovery of the K+ current to the resting state after the calcineurin-dependent dephosphorylation of TRESK."
30992311
sparser
"Dephosphorylation of TRESK by calcineurin can be blocked in cells pretreated with calcineurin inhibitors (FK506 or cyclosoprin A)."
18190784
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"In contrast, exogenous application of tacrolimus or a calcineurin siRNA to cultured or in vivo DRGs increases TRESK phosphorylation and produced opposite effects (increase) on excitability and pain sensitivity."
32717813
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"TREK-2 phosphorylated by PKC shows low channel activity [40], whereas TRESK dephosphorylated by calcineurin shows high channel activity [41]."
27382354