IndraLab

Statements

DEPDC5 binds USP46. 4 / 4
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sparser
"To further validate the interaction between DEPDC5 and USP46, we performed co-immunoprecipitation between DEPDC5 and USP46 from cytosolic fractions and the proximity ligation assay (PLA)."
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sparser
"Taken together, the results indicate that, in addition to the USP46-DEPDC5 interactions, mTORC1 hyperactivity is necessary to increase the excitatory synaptic strength."
40467011
sparser
"The number of PLA-positive puncta between DEPDC5 and USP46 was significantly higher than those observed in the negative control and comparable with the number of puncta observed in the βIII-tubulin/MAP2 positive control, confirming the interaction between DEPDC5 and USP46 ( xref C)."
40467011
sparser
"Notwithstanding the direct interaction between Depdc5 and USP46, the observed increase in the excitatory synaptic strength in Depdc5 cKO neurons is not independent of mTORC1 hyperactivity."
40467011