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Anthra[1,9-cd]pyrazol-6(2H)-one inhibits FOS. 2 / 2

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"TGFβ also induced phosphorylation of (S351) NR4A1, JNK1, c-jun and c-fos which was also inhibited by SP600125, demonstrating that TGFβ induces JNK and genes downstream from JNK."

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"Moreover, the present study showed that IL-17A induced the nuclear translocation of c-Jun and c-Fos, which could be effectively inhibited by the JNK inhibitor SP600125 or the p38 inhibitor SB203580 (Fig. 6a)."

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Anthra[1,9-cd]pyrazol-6(2H)-one inhibits FOS. 2 / 2

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