IndraLab

Statements

Metformin inhibits NFKB1. 6 / 6
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"Metformin combined with CO-1686 synergistically inhibited the p-IkappaB, p-IKKa and beta, p50 and p65."
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"Furthermore, in primary breast cancer cell lines, metformin presents an inhibitory effect on tumor invasion and metastasis due to the dual suppression of NF-kB activity and nuclear translocation mediated by MMP-9 downregulation [119], and in prostate cancer models, metformin appeared to attenuate metastasis by repressing NF-Kb signaling, thus leading to the suppression of tumor necrosis factor-α-induced EMT [120]."
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"Metformin downregulates nuclear factor kappa B subunit 1 (NFKB), an important regulator of inflammation and decreases production of pro-inflammatory cytokines."
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"These results suggest that metformin blocks SCC growth by dampening NFkB and mTOR signaling pathways."
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"Metformin has been reported to inhibit NF-kb via adenosine monophosphate protein kinase (AMPK) activation ( Isoda et al., 2006 ), which could explain our results of the combined therapy being more eff[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Metformin also inhibits endometrial cancer cell migration, by altering the activities of NFkB, MMP-9, and MMP-2, key protein complexes and proteases involved in cell migration and metastases."
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