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JAK2 phosphorylates STAT3 on tyrosine. 47 / 50
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"In contrast, AG490, an inhibitor of JAK2, predominantly prevented tyrosine phosphorylation at tyrosine residue 701 of STAT1 but only partially inhibited tyrosine phosphorylation of STAT3."
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"Dominant negative JAK1 or JAK2 was able to block the IGF-IR-mediated tyrosine phosphorylation of STAT3 in 293T cells."
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"In U87MG, LN229, and GSC23 cells, alectinib induced dose‐dependent suppression of the tyrosine phosphorylation of STAT3 and activation of the tyrosine phosphorylation of janus kinase 2 (JAK2), which induces tyrosine phosphorylation of STAT3 (Figure 5A)."
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"JAK2 phosphorylates STAT3 on tyrosine leading to dimerization and nuclear localization, whereas MAPK phosphorylates STAT3 on serine 727, leading to maximal transcriptional activation of STAT3 [42]."
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"Furthermore, our study reveals that PDGF-BB- and bFGF induced proliferation does not affect the osteogenic differentiation potential of hBMMSCs.All of the three GFs activated the hBMMSC ERK1/2 pathway[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This induction was significantly reduced by AG490 treatment, an inhibitor of JAK2 tyrosine kinase that phosphorylates STAT3 as well as STAT1 ( Gorina et al., 2005 ) ( Figure 1 E)."
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"LPS induces the phosphorylation of the JAK1 and JAK2, which then upregulates tyrosine phosphorylation of STAT1 and STAT3, respectively (O'Shea and Plenge, 2012)."
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"Furthermore, PDGF-BB-induced STAT3 tyrosine and serine phosphorylation in hBMMSCs are directly mediated by JAK2 and ERK1/2, respectively."
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"Tyrosine residue in STAT3 is phosphorylated by JAK or Src family kinases in response to cytokines or growth factors."
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"Binding of IL-5 to its specific receptor activates JAK2 which leads to the tyrosine phosphorylation of STAT3 proteins."
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"During this process, STAT3 was phosphorylated by the tyrosine kinase JAK2 that was recruited to the a7 subunit of the nicotinic acetylcholine [XREF_BIBR]."
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"This regulation involves the phosphorylation of the transcription factor STAT3 by the tyrosine kinase Jak2 recruited to the α7 subunit of the nicotinic acetylcholine receptor [20] ."
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"Upon cytokine stimulation, Janus kinase 2 (JAK2) phosphorylates STAT3 at tyrosine residues, which leads to the dimerization of STAT3 via reciprocal interactions between the SH2 domain of one monomer and the phosphorylated tyrosine of the other."
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"One of these pathways activated in alveolar epithelial cells in mice with pneumonia is signal transducer and activator of transcription 3 (STAT3). xref Cytokines like interleukin (IL)-6 can activate phosphorylation of tyrosine residues of STAT3 by Janus kinase 2 (JAK2). xref Once phosphorylated, STAT3 translocates into the nucleus where it binds to specific promoter sequences and regulates transcription of genes that mediate host immune response."
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"JAK1 and JAK2 are known upstream kinases for tyrosine phosphorylation of STAT3, and overactivated in some types of cancer."
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"Upon activation, STAT3 is phosphorylated by the non receptor protein tyrosine kinases janus kinase 2 (JAK2), leading to the formation of STAT3 dimer and translocation into the nucleus [XREF_BIBR, XREF_BIBR]."
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"Consistent with these observations, we found that deletion of SH2-B impaired leptin-stimulated JAK2 activation and tyrosine phosphorylation of both STAT3 and IRS2 in the hypothalamus."
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"XREF_BIBR SD-1029 appears to act by inhibiting the kinase JAK2, which mediates STAT3 tyrosine phosphorylation in a range of tumor types."
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"Researchers found PPARgamma agonists blocked the cytokines induced tyrosine phosphorylation of STAT3 transcription factors and the upstream JAK2 in cells [27]."
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"Additionally, Janus kinase 2 (JAK2) and tyrosine kinase 2 (TYK2) were recruited onto MyD88 to induce the phosphorylation and activation of the transcription factor signal transducer and activator of transcription-3 (STAT-3)."
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"The second cascade would be a signaling pathway through PI3K, activated or not by JAK2, which could phosphorylate STAT3 via other non receptor tyrosine kinases like BMX XREF_BIBR."
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"Upon leptin binding and clustering of activated receptor complexes, Janus Kinase 2 (JAK2) phosphorylates intracellular tyrosine residues, which recruit transcription factors : Src Homology Phosphatase 2 (SHP2), Signal Transduscer and Activator of Transcription 5 (STAT5), and STAT3."
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"STAT3 was phosphorylated by the tyrosine kinase Jak2 that was recruited to the alpha7 subunit of the nicotinic acetylcholine receptor."
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"IL-23 promotes signal transducer and transcriptional activator 3 (STAT3) phosphorylation by Janus kinase 2 (JAK2) and tyrosine kinase 2 (TYK2) by binding to its receptor IL-23R."
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"Stimulating them, leptin can activate JAK2 kinase which induces the tyrosine phosphorylation of the STAT3, SHP2, and PI3K proteins."
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"These results suggest that JAK2 and ERK may mediate tyrosine and serine phosphorylation of STAT3 induced by histamine, respectively, and that both phosphorylations may be required for the activation o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"WP1066 is a JAK-2 kinase inhibitor that blocks STAT3 tyrosine phosphorylation, and has proapoptotic and antiproliferative activity in a variety of cancers, including glioma [XREF_BIBR, XREF_BIBR]."
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"JAK2 activation leads to tyrosine phosphorylation of STAT3, which then translocates to the nucleus and acts as a transcription factor by binding to response elements in the promoter of leptin target g[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The histamine induced enhancement of activity or tyrosine and serine phosphorylation of STAT3 were suppressed by pyrilamine, but not by cimetidine or thioperamide, which suggests the involvement of H1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The stimulation of JAK2 activity then in turn enhances STAT1 and STAT3 Tyr phosphorylation and DNA binding activity, which identifies STAT transcription factors as downstream targets of CER."
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"Tyrphostin AG490, a specific inhibitor of Jak-2, significantly reduced tyrosine phosphorylation and DNA binding activity of STAT-3 and DNA synthesis induced by 5 (S)-HETE."
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"In addition, JAK2 may directly tyrosine phosphorylate APRF, an ISGF like factor that rapidly migrates to the nucleus and binds to the hexanucleotide CTGGGA."
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"When the body encounters cytokines, inflammation, malignant tumors, immune factors or other factors, JAK2 is activated to phosphorylate the C-terminal tyrosine residue of STAT3 in the cytoplasm."
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"On the other hand, STAT3, a potential negative regulator of inflammatory responses, is phosphorylated by the tyrosine kinase Jak2 that is recruited to the α7 nAChR."
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"It was postulated that IL-23 promotes signal transducer and transcriptional activator 3 (STAT3) phosphorylation by Janus kinase 2 (JAK2) and tyrosine kinase 2 (TYK2) by binding to its receptor IL-23R (70, 71)."
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"Once the gp130 receptor is activated, it induces downstream Janus kinase 2 (JAK2) phosphorylation of the tyrosine residue on STAT3."
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"Once the gp130 receptor is activated, it induces downstream Janus kinase 2 (JAK2) phosphorylation of the tyrosine residue on STAT3."
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"32, 33 In the pathogenesis of cancer, elevated IL-6 and IL-27 could stimulate the activation of JAK1 and JAK2 enzymes, which subsequently mediate tyrosine phosphorylation of STAT3 at Tyr705."
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"IL-23 signaling activates the expression of interleukin 17 (IL-17) with Th17-associated gene transcription factor, STAT3 phosphorylated by Janus kinase 2 (Jak2) and tyrosine kinase 2 (Tyk2)."
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"STAT3 was phosphorylated by the tyrosine kinase Jak2, which is recruited to the alpha7 subunit of the nicotinic acetylcholine receptor."
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"More specifically, CNTF activates JAK1, JAK2 and TYK2 tyrosine kinases which phosphorylate STAT3 tyrosine in position 705 [38-42]."
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"Previous publication [26] and our observations showed that Ang II-induced tyrosine phosphorylation of STAT3 in VSMCs was mediated by Src but not JAK2, and preventing Src signaling to STAT3 could block[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"After the stimulation of IL-17 T cells with IL-23, STAT3 is phosphorylated by JAK2 and Tyrosine kinase 2 (TYK2) and then induces the transcription factor RORγt. pSTAT3 and RORγt bind to IL17A and IL17F promoters and induce the expression of IL-17 (6)."
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"Upon cytokine stimulation, Janus kinase 2 (JAK2) phosphorylates STAT3 at tyrosine residues, which leads to the dimerization of STAT3 via reciprocal interactions between the SH2 domain of one monomer and the phosphorylated tyrosine of the other."
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"STAT3 phosphorylation by the tyrosine kinase Jak2 recruited to the alpha7nAChR is an underlying intracellular mechanism in this model."
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"JAK2 inhibition prevented STAT3 tyrosine phosphorylation and NF-kappaB activation."
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"Cytokines like interleukin (IL)-6 can activate phosphorylation of tyrosine residues of STAT3 by Janus kinase 2 (JAK2)."
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