IndraLab

Statements

TCF4 binds CTNNB1 and LEF1. 12 / 12
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"In addition, CGP049090, which blocks the binding of β-catenin to TCF4 and Lef1 [ xref ], was not as effective as PKF115-584."
23965253
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"Because proinflammatory cytokine-induced cartilage degradation appears to involve WNT/β-catenin signaling and increased WNT/β-catenin signaling has been implicated in the initiation and progressive deterioration of cartilage degeneration, we hypothesized that small molecule inhibitors of the interaction between β-catenin and TCF4 and Lef1 could be used to prevent cytokine-induced cartilage degradation."
23965253
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"Β-catenin binds TCF-4 or LEF-1 to regulate cognate gene expression."
21744004
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"Given the difference in the structures of TCF-4 and Lef-1 bound to β-catenin, it was of interest to compare the thermodynamics of these complexes."
21075118
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"We observed that in both cases β-CATENIN protein–protein interactions with either LEF-1 or TCF-4 were dramatically decreased after ICG-001 treatment."
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"In addition, β-catenin also translocates into the nucleus and interacts with LEF-1 and TCF-4 at the COX2 promoter to activate the transcription of COX2."
28587064
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"Our Chromatin immunoprecipitation assay demonstrated a strong binding of β-catenin to the TCF-4 and LEF-1 sites located around -703 and -685 regions of the PDGF-B gene promoter in the KPA cancer cells, while no significant binding was found in the KPC cancer cells (Figure xref D)."
30809277
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"Upon translocation to the nucleus, β-catenin interacts with Tcf4 and Lef1 to regulate a wide range of gene expression at the transcriptional level [ xref ]."
20858269
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"In addition, the interaction between β-catenin with TCF4 or LEF1 was also enhanced in mPGES-1 overexpressed cells but decreased in mPGES-1 knockdown cells."
21743491
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"Here, we present ITC measurements of Lef-1 and Tcf4 binding to β-catenin under identical conditions, which show that Lef-1 binds slightly less strongly than Tcf4 to β-catenin."
21075118
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"APC mutations and β- catenin gene mutations increase the association of β-catenin with the TCF-4 and Lef-1, xref xref which are involved in the transcriptional regulation of E-cadherin xref and possibly, of other target genes and provide evidence of functional interaction between signaling pathways and cell adhesion molecules during tumorigenesis."
21772890
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"Similarly, the interaction between nuclear β-catenin and TCF-4 or LEF-1 was reduced by CaSR activation ( Fig. 6D ), indicating an inhibitory association of β-catenin and TCF-4 or LEF-1 in the nucleus."
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