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Estrogen inhibits KCNQ1. 5 / 5
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"The molecular mechanisms leading to KCNQ1 inhibition by estrogen involves PKCδ and PKACI activation, and subsequent KCNE3 phosphorylation and dissociation from KCNQ1 causing a rapid decrease in channe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The molecular mechanisms leading to KCNQ1 inhibition by estrogen involves PKCδ and PKACI activation, and subsequent KCNE3 phosphorylation and dissociation from KCNQ1 causing a rapid decrease in channe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Estrogen, for example, inhibits KCNQ1 channel activity by PKCδ phosphorylation of KCNE3 causing dissociation of the channel complex and collapse of channel conductance [82] ."
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"We have previously shown that estrogen causes a female-gender specific inhibition of KCNQ1 channels in rat colonic crypts, producing an antisecretory response which is also dependent on PKA activation and association with the KCNQ1 channel."
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"Therefore, in distal colonic cells estrogen inhibition of KCNQ1 activity leads to the inhibition of transepithelial chloride secretion."
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