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Estrogen inhibits KCNQ1. 2 / 2
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"Therefore, in distal colonic cells estrogen inhibition of KCNQ1 activity leads to the inhibition of transepithelial chloride secretion."
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"We have previously shown that estrogen causes a female-gender specific inhibition of KCNQ1 channels in rat colonic crypts, producing an antisecretory response which is also dependent on PKA activation and association with the KCNQ1 channel."
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