IndraLab

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FOXO1 decreases the amount of SCN5A. 3 / 3
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"In human, the transcription of SCN5A is repressed by FOXO1, whose transcriptional repression activity is in turn inactivated by AKT1-dependent phosphorylation [52] (Fig 3B)."
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"XREF_BIBR - XREF_BIBR A recent study has indicated that FOXO1 negatively regulates SCN5A transcription, XREF_BIBR and effect that can be inhibited by Akt induced phosphorylation and translocation of FOXO1 from the nucleus to the cytoplasm."
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"Because FOXO1-mRNA was unchanged and phosphorylated form of FOXO1 was increased in the nucleus in response to NO (Fig. 7A,B), and because NOC-18 suppressed Nav1.5 protein expression accompanied by a perinuclear aggregation of FOXO1 protein (Fig. 7E), it is suggested that FOXO1 translocates from the cytoplasm to the nucleus and suppresses the expression of Nav1.5."
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