IndraLab

Statements

FOXO1 decreases the amount of SCN5A. 5 / 5
| 5
reach
"XREF_BIBR - XREF_BIBR A recent study has indicated that FOXO1 negatively regulates SCN5A transcription, XREF_BIBR and effect that can be inhibited by Akt induced phosphorylation and translocation of FOXO1 from the nucleus to the cytoplasm."
23393573
reach
"Because FOXO1-mRNA was unchanged and phosphorylated form of FOXO1 was increased in the nucleus in response to NO (Fig. 7A,B), and because NOC-18 suppressed Nav1.5 protein expression accompanied by a perinuclear aggregation of FOXO1 protein (Fig. 7E), it is suggested that FOXO1 translocates from the cytoplasm to the nucleus and suppresses the expression of Nav1.5."
34050231
reach
"In HL-1 cells it was described that FoxO1 reduced Nav1.5 expression by repressing the Scn5a promoter activity [171] ."
35963339
reach
"In human, the transcription of SCN5A is repressed by FOXO1, whose transcriptional repression activity is in turn inactivated by AKT1-dependent phosphorylation [52] (Fig 3B)."
31125330
reach
"Moreover, FoxO1 deletion increased Nav1.5 and Navβ3 mRNA expression and I Na density, which accelerated AP depolarization velocity in mouse ventricular cardiomyocytes [172] ."
35963339