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CYLD activates Receptors, Antigen, B-Cell. 2 / 2

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"In addition, NF-kappaB deubiquitinases CYLD and A20, which negatively regulate canonical NF-kappaB signaling, can induce NF-kappaB downstream of the BCR in miR-17 ~ 92 overexpressing B cells, and thus, have also been proposed as targets of oncomiR-1, [XREF_BIBR]."

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"22 Moreover, CYLD ablation induced BcR signaling activation, as attested by elevated BTK phosphorylation at Tyr223 as well as activation of the downstream PI3K/AKT and MEK/ERK signaling pathways 39 in CYLD KO clones."

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CYLD activates Receptors, Antigen, B-Cell. 2 / 2

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