IndraLab

Statements

Acetylated TP53 increases the amount of CDKN1A. 11 / 11
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"On the one hand, PARP inhibitors sensitized wild type but not NMNAT1 KO cells to ActD-induced anti-clonogenic effects; on the other hand, over-acetylated p53 induced the expression of the anti-proliferative p21 protein leading to cell cycle arrest."
| PMC
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"Mechanistically, acetylation of p53 is thought to enhance its ability to bind DNA ( Gu and Roeder, 1997 ), recruit the transcriptional coactivators p300/CBP to p53-responsive promoters ( Barlev et al.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The up-regulated acetylation of p53 promoted the transcriptional activity of p53 and induced the expression of p21, which consequently caused cell cycle arrest at G1 phase."
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"Acetylated p53 increases the expression of p21 and further promotes apoptosis in A549 cells."
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"The acetylation of p53 induces subsequent expression of p21, leading to the induction of cellular senescence."
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"On the other hand, acetylation of K382 on p53 promotes recruitment of p300 to p21 promoter, leading to increased histone acetylation on the promoter region and subsequently p21 transcription [73]."
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"At least in part, HDACi induce cell-cycle arrest by causing accumulation of hyperacetylated p53, which then induces expression of p21, leading to inhibition of cyclins D and A, which are required for cell-cycle progression."
26124919
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"On the one hand, PARP inhibitors sensitized wild type but not NMNAT1 KO cells to ActD-induced anti-clonogenic effects; on the other hand, over-acetylated p53 induced the expression of the anti-proliferative p21 protein leading to cell cycle arrest."
34445574
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"Moreover, loss of p53 acetylation diminished PUMA, BAX, and p21 expression levels [41] , showing its importance in the general functions of p53."
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"The acetylated p53 enhanced p21 and BAX expression and induced apoptosis."
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"Down-regulation of MsrA induces an increase in p21 levels by enhanced p53 acetylation, which consequently inhibits cell growth at G 2 /M stage."
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