"The acetylated p53 enhanced p21 and BAX expression and induced apoptosis."
"Acetylated p53 increases the expression of p21 and further promotes apoptosis in A549 cells."
"The up-regulated acetylation of p53 promoted the transcriptional activity of p53 and induced the expression of p21, which consequently caused cell cycle arrest at G1 phase."
"The acetylation of p53 induces subsequent expression of p21, leading to the induction of cellular senescence."
"At least in part, HDACi induce cell-cycle arrest by causing accumulation of hyperacetylated p53, which then induces expression of p21, leading to inhibition of cyclins D and A, which are required for cell-cycle progression."