IndraLab

Statements

Acetylated TP53 increases the amount of CDKN1A. 7 / 7
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"The up-regulated acetylation of p53 promoted the transcriptional activity of p53 and induced the expression of p21, which consequently caused cell cycle arrest at G1 phase."
29334665
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"On the one hand, PARP inhibitors sensitized wild type but not NMNAT1 KO cells to ActD-induced anti-clonogenic effects; on the other hand, over-acetylated p53 induced the expression of the anti-proliferative p21 protein leading to cell cycle arrest."
34445574
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"The acetylation of p53 induces subsequent expression of p21, leading to the induction of cellular senescence."
30156909
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"Acetylated p53 increases the expression of p21 and further promotes apoptosis in A549 cells."
30988280
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"On the one hand, PARP inhibitors sensitized wild type but not NMNAT1 KO cells to ActD-induced anti-clonogenic effects; on the other hand, over-acetylated p53 induced the expression of the anti-proliferative p21 protein leading to cell cycle arrest."
| PMC
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"At least in part, HDACi induce cell-cycle arrest by causing accumulation of hyperacetylated p53, which then induces expression of p21, leading to inhibition of cyclins D and A, which are required for cell-cycle progression."
26124919
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"The acetylated p53 enhanced p21 and BAX expression and induced apoptosis."
26044764