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IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

Acetylated TP53 increases the amount of CDKN1A. 5 / 5
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"The acetylated p53 enhanced p21 and BAX expression and induced apoptosis."
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"Acetylated p53 increases the expression of p21 and further promotes apoptosis in A549 cells."
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"The up-regulated acetylation of p53 promoted the transcriptional activity of p53 and induced the expression of p21, which consequently caused cell cycle arrest at G1 phase."
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"The acetylation of p53 induces subsequent expression of p21, leading to the induction of cellular senescence."
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"At least in part, HDACi induce cell-cycle arrest by causing accumulation of hyperacetylated p53, which then induces expression of p21, leading to inhibition of cyclins D and A, which are required for cell-cycle progression."