IndraLab

Statements

USP10 activates FN1. 6 / 6
| 6
reach
"Furthermore, the fact that biochemical endpoints that are equalized by protein, not microscopic images (western blots and immunoprecipitation of cell-surface integrins),13 demonstrate a more than two-fold difference in cell-surface integrin accumulation13 and FN internalization by ELISA (see below) when USP10 is overexpressed supports the idea that USP10 increases cell-surface integrin expression, not simply larger cells.Because cell-surface integrin expression is increased in USP10 overexpressing cells, and FN is endocytosed via integrins, we next asked if USP10 overexpression increased uptake of FN."
34665194
reach
"USP10 Promotes Fibronectin Recycling, Secretion, and Organization."
34665194
reach
"USP10 overexpressing cells increased FN uptake by 2.2-fold (P < 0.05) (Fig. 1G)."
34665194
reach
"These controls demonstrate that the USP10-mediated increase in recycled FN is not derived from a significant overall increase in cell number."
34665194
reach
"Targeted silencing of USP10 by siRNA approach in wounded porcine corneas improved the stromal ECM arrangement, suppressed fibrosis gene expression (αSMA and fibronectin), and reduced immune cell infiltration [162]."
38540264
reach
"Interestingly, even though USP10 increased both recycled FN and secreted FN-EDA and therefore the total FN, the relative ratios of recycled and FN-EDA between control and USP10 cDNA were not significantly different."
34665194