IndraLab

Statements

Dronedarone inhibits KCNH2. 11 / 11
2 1 2 | 5 1
reach
"RIDLEY JM, MILNES JT, WITCHEL HJ, HANCOX JC : High affinity HERG K+ channel blockade by the antiarrhythmic agent dronedarone : resistance to mutations of the S6 residues Y652 and F656."
17298291
drugbank
No evidence text available
17896959
reach
"Dronedarone blocked HERG channels with an IC50 value of 9.2 microM and a maximum tail current reduction of 85.2%."
14517175
reach
"The half-maximal activation voltage was shifted by -6.1 mV, and HERG current block by dronedarone was voltage dependent, but not use dependent."
14517175
tas
No evidence text available
21185626
tas
No evidence text available
15324906
drugbank
No evidence text available
23997577
sparser
"The L532P mutation produced an ~ 5-fold increase in the IC 50 for dronedarone inhibition of I hERG ."
21777565
reach
"However, some exceptions have been found, vesnarinone does not require Y652 ( Kamiya et al., 2001 ) and fluvoxamine and dronedarone, which can block HERG when F656 and Y652 are mutated ( Milnes et al.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16423345
reach
"Dronedarone inhibits the I (Kv7.1) and I (Kv11.1) currents.Finally, there are classic drugs that find their therapeutic niche in patients with preserved cardiac function and no structural abnormalities [88]."
37629037
ctd
No evidence text available
15618689