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ADAM17 phosphorylates NGFR. 2 / 2
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"We show that Trk-induced ADAM17 phosphorylation and generation of the p75NTR(ICD) is required for neurotrophin-induced Erk and Akt activation and for neurotrophin-dependent survival signaling."
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"More recently, it has been described that in PC12 cells and in primary cerebellar granule neurons, NGF activation of TrkA leads to ADAM17 phosphorylation and generation of the p75 NTR ICD, which in tu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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