IndraLab

Statements

COPS5 increases the amount of TP53. 5 / 5
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"Our results demonstrated that CSN5 down-regulation by CSN5 siRNA or curcumin triggered significant p53 protein expression in cancer cells."
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"In cancer cells, CSN5 -overexpression would further promote low p53 levels and thus promote tumorigenesis."
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"RNA interference (RNAi) of Jab1 restored the levels of the downregulated p53 and Smad4."
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"In conclusion, this study revealed that ESD increased the protein level of p53 in the nucleus by JAB1 to inhibit the cell cycle of A549 lung cancer cells."
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"Furthermore, we found that downregulation of Jab1 induces the cell cycle arrest at G1 phase and upregulated the expression of p27, p53 and Bax gene."
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