IndraLab

Statements

Adenosine inhibits CASP1. 3 / 3
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"The PKA inhibitor KT5720 blocks activation of caspase-1 by adenosine."
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"Peripheral administration of adenosine in wild-type (WT) mice led to a 2.3-fold increase in caspase-1 activity in the amygdala and to a 33% and 42% reduction in spontaneous locomotor activity and food intake, respectively, that were not observed in caspase-1 knockout (KO), IL-1 receptor type 1 (IL-1R1) KO and A2A AR KO mice or in mice administered a caspase-1 inhibitor centrally."
24907587
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"Inhibition of potassium efflux prevents adenosine dependent activation of caspase-1 in the brain."
24907587