IndraLab

Statements

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"These results are consistent with the RNA-seq data indicating that HCQ inhibits cholesterol metabolism, suggesting that further impairing cholesterol production is synthetic lethal to HCQ treated cells."
32869031
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"Hydroxychloroquine (HCQ) seems to reduce cholesterol, triglycerides, glycemia and blood pressure, and also has anti-aggregant effects, but we still do not know whether it can protect SLE patients from[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20692379
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"Furthermore, in the study of Cairoli et al. [70] , hydroxychloroquine induced a significant decrease of total and LDL cholesterol after 3 months of treatment, likely due to improvement of cholesterol [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24331863
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"However, the temporal statin-induced increase in cholesterol precursors lanosterol, zymostenol, and desmosterol observed in the placebo group were inhibited by HCQ."
37448694
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"Also important to its anti-atherosclerotic potential, hydroxychloroquine treatment has been shown to reduce total serum cholesterol [XREF_BIBR - XREF_BIBR]."
24672580
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"Regarding the lack of effect on zymostenol and lathosterol, one possibility is that the localizations of the enzymes affected by HCQ in the cholesterol synthesis pathway are strictly regulated.Third, in high cholesterol absorbers, HCQ lowered serum cholesterol by interfering with the cholesterol-synthesis pathway."
38487037
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"A recent systematic review and meta-analysis involving data from nine studies and 823 participants has stated that HCQ significantly reduced mean total cholesterol plasmatic levels (26.8 mg/dL; 95% CI 8.3-45.3), as well as mean LDL serum levels (24.3 mg/dL; CI95% 8.9-39.8)."
32517786
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"An Indian randomized controlled phase 3 trials showed that HCQ ( 400 mg ) as compared to pioglitazone ( 15 mg ) lowers HbA1c , LDL cholesterol levels and lead to weight loss in patients with type 2 diabetes [ 12 ] ."
32594451
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"It cannot be ruled out that in high cholesterol absorbers, HCQ might also delay the absorption of cholesterol and cholesterol precursors, or simply its higher concentration explains the more powerful effect.In high cholesterol absorbers, HCQ reduced serum cholesterol concentration and lanosterol and desmosterol ratios at one and 12 months compared with the placebo group."
38487037
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"On the other hand, hydroxychloroquine has been reported to decrease total and LDL cholesterol and triglyceride concentrations [XREF_BIBR]."
20157365
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"In systematic reviews and meta-analyses, including almost 40,000 patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE), HCQ significantly reduced serum total cholesterol (total-c) and low-density lipoprotein (LDL) cholesterol (LDL-c) concentrations from baseline values in comparison to HCQ non-users [[1], [2], [3]]."
37448694
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"Combination therapy with MTX, sulfasalazine, and hydroxychloroquine also decreases CV risk by improving inflammation reduction, increasing HDL, lowering LDL, and improving the ratio of total cholesterol to HDL, as against MTX monotherapy or in combination with etanercept."
37763669
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"Particularly, HCQ has been shown to decrease LDL and VLDL cholesterol, along with an elevation of plasmatic concentration of HDL [59]."
26212119
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"HCQ can reduce serum cholesterol, triglyceride, and LDL levels [38] and insulin degradation [39]."
21417950
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"Our findings also suggest that HCQ may be able to reverse some of the adverse effects of high cholesterol loading common to high-risk patients."
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