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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TNF bound to IRF8 activates TNFAIP3. 1 / 1

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"Aberrations in TNF signaling were apparent with upregulation of both TNF and TNF receptor superfamily members but universal downregulation of IRF8 bound TNF induced TNFAIP3, a negative regulator of cytokine mediated immune and inflammatory responses."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...