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USP22 deubiquitinates COL17A1. 4 / 4
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"Mechanistically, USP22 stabilized and upregulated COL17A1 by enhancing the deubiquitination of COL17A1."
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"In addition, the reduced expression of the ferroptosis suppressor GPX4 was observed in sh‐COL17A1 xenograft tumors (Figure 4D).3.5 USP22 Promotes the Deubiquitination of COL17A1 to Stabilize COL17A1."
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"In this paper, we establish the fact, for the first time, that USP22 stabilizes COL17A1 by deubiquitinating COL17A1 in LUAD cells, highlighting a novel deubiquitination mechanism underlying COL17A1 upregulation in LUAD."
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"More intriguingly, in A549 LUAD cells, immunoblot analysis with an antibody against ubiquitin (UB) after IP experiments using the anti‐COL17A1 antibody revealed that USP22 silencing resulted in a distinct increase in ubiquitinated COL17A1 protein level and COL17A1 degradation (Figure 5M), suggesting that USP22 induces the deubiquitination of the COL17A1 protein in LUAD cells."
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