IndraLab

Statements

USP2 binds ARID2. 13 / 13
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"USP2 Is Significantly Suppressed and Interacts with ARID2 in Lung Cancer Cells."
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"Based on the above findings, we then utilized HEK-293T cell line as a model to explore and confirm the potential interaction of USP2-ARID2."
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"Using anti-Flag or anti-Myc antibody precipitated protein as input, interactive Myc-USP2 protein (Supplementary Figure 1 B) and interactive Flag-ARID2 (Supplementary Figure 1 C) were, respectively, detected; the above findings provided direct evidence of the interaction of USP2 and ARID2 in cell line models."
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biogrid
No evidence text available
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"Using anti-Flag or anti-Myc antibody precipitated protein as input, interactive Myc-USP2 protein (Supplementary Figure xref ) and interactive Flag-ARID2 (Supplementary Figure xref ) were, respectively, detected; the above findings provided direct evidence of the interaction of USP2 and ARID2 in cell line models."
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biogrid
No evidence text available
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"The results indicated that in both A549 and H1299 cells, ARID2 protein can be detected in anti-USP2 antibody precipitated protein samples, and vice versa ( xref ), suggesting endogenously USP2-ARID2 protein-protein interaction (PPI) in lung cancer cells."
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biogrid
No evidence text available
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"The quantitative analysis of the USP2-ARID2 colocalization ratio also provided consistent results (Figures xref and xref )."
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"To explore the potential role of proteasome-dependent protein degradation in USP2-ARID2 regulation, MG132 was then applied in A549 cells transfected with USP2 overexpression vectors."
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"To validate our findings of the USP2-ARID2 regulatory axis in lung cancer cell line models, USP2 protein and mRNA expression were further detected in paired and unpaired clinical lung cancer and normal tissue (NT)."
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"The results of our study further expand the regulatory function of ARID2 in lung cancer cell invasiveness and EMT process and suggest the potential of the USP2-ARID2 axis as a novel target in future therapy development for lung cancer."
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"Co-IP assays were designed to validate USP2-ARID2 protein interaction."
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