IndraLab

Statements

USP22 activates ZEB1. 4 / 4
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"Reduction of ZEB1 caused by knockdown of USP22 was also prevented by MG132, on the other hand, USP22 depletion accelerated ZEB1 degradation with the treatment of cycloheximide (CHX), which is protein synthesis inhibitor, in HCC-derived cells (Fig. 4D–F and Supplementary Fig. S5A)."
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"While USP22 depletion decreased ZEB1 protein, not mRNA level (Fig. 6E, F and Supplementary Fig. S7A)."
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"According to the results of previous studies, USP22 can induce EMT by regulating TGF-beta1 in lung cancer cells [XREF_BIBR], and elevated USP22 expression can promote EMT by up-regulating ZEB1 and Snail in pancreatic cancer cells though a process that involves focal adhesion kinase (FAK) signaling [XREF_BIBR]."
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"ZEB1 has illustrated to be modulated by USP7, USP22 and USP51 in cancers."
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