IndraLab

Statements


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"Catalytic inactivation of USP8 incurs EGFR hyperubiquitination and promotes receptor localization to endosomes marked by high ubiquitin content."

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"Moreover, Shi RNAi attenuated the localization of Smo in the early endosomes (XREF_FIG), whereas USP8 RNAi elevated the localization (XREF_FIG)."

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"USP8 has been demonstrated to selectively remove K6-linked UB chains from Parkin and promote Parkin localization to depolarized mitochondria (80, 81)."