IndraLab

Statements

USP8 binds BIRC6 and BRIT1. 6 / 6
| 6
reach
"Given the fact that the integrity of the BRUCE, USP8, and BRIT1 complex is essential for targeting BRIT1 to DSB, whether the observed UBC requirement is attributable to its contribution to maintaining the complex integrity was examined."
26683461
reach
"Mutation or deletion of the BRUCE UBC domain did not disrupt the BRUCE, USP8, and BRIT1 complex, but impaired deubiquitination and consequent recruitment of BRIT1 to DSB."
26683461
reach
"Once deubiquitinated, BRIT1 is released from the BRUCE, USP8, and BRIT1 complex and targeted to DSBs by binding to gamma-H2AX at sites of DSB [XREF_BIBR], where BRIT1 recruits the SWI/SNF chromatin remodeling complex to facilitate relaxation of chromatin configuration for the access of repair factors to damaged chromatin [XREF_BIBR]."
26683461
reach
"The formation of the BRUCE, USP8, and BRIT1 complex in unstimulated cells is mediated by N-terminal half of BRUCE (N-BRUCE)."
26683461
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"This deubiquitination triggers the release of BRIT1 from the BRUCE, USP8, and BRIT1 complex and consequently released BRIT acquires the ability to be recruited to sites of DNA damage by binding to phosphorylated H2AX (gamma-H2AX)."
26191375
reach
"Together, these results indicate that subsequent to the formation of the BRUCE, USP8, and BRIT1 complex mediated by N-BRUCE, the C-BRUCE is required for targeting BRIT1 to DSB sites."
26683461