IndraLab

Statements

CYLD inhibits CYLD. 8 / 9
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"Additionally, phosphorylation of CYLD was found to downregulate CYLD activity : transient phosphorylation by IKK in a serine cluster just upstream of the TRAF2 binding site, attenuates DUB function XREF_BIBR."
23335970
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"The CYLD staining and protein expression were lower in the OX-LDL+ Sal A group than OX-LDL group after culturing for 48 hours (P < 0.01, Figures XREF_FIG - XREF_FIG and XREF_FIG), revealing that OX-LDL increases CYLD level and Sal A antagonizes OX-LDL by downregulating CYLD."
29081889
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"Together, these observations demonstrate that IKKepsilon mediated phosphorylation of CYLD at Ser418 inhibits CYLD deubiquitinase activity."
19481526
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"Phosphorylation of CYLD at Ser418 decreases CYLD activity."
19481526
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"However, constitutive phosphorylation of CYLD by IKK inactivates CYLD in HTLV-1-induced leukemia to promote heightened NF-kappaB activation."
22435550
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"These results demonstrate that phosphorylation of CYLD at Ser418 suppresses CYLD activity, resulting in increased NF-kappaB transcriptional activation."
19481526
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"As IKK mediated phosphorylation of CYLD has been reported to negatively regulate CYLD enzymatic activity [XREF_BIBR], we further explored whether IKK is also involved in regulating the degradation of CYLD by SCF beta-TRCP."
24961988
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"Interestingly, recent findings also suggest that OTULIN deficiency results in spontaneous inhibitory phosphorylation of CYLD, thereby limiting CYLD activity, which can be rescued by LUBAC inhibition [XREF_BIBR]."
33288901