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CYLD inhibits CYLD. 14 / 15
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"The CYLD staining and protein expression were lower in the OX-LDL+ Sal A group than OX-LDL group after culturing for 48 hours (P < 0.01, Figures XREF_FIG - XREF_FIG and XREF_FIG), revealing that OX-LDL increases CYLD level and Sal A antagonizes OX-LDL by downregulating CYLD."
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"Phosphorylation of CYLD at Ser418 decreases CYLD activity."
19481526
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"Additionally, phosphorylation of CYLD was found to downregulate CYLD activity : transient phosphorylation by IKK in a serine cluster just upstream of the TRAF2 binding site, attenuates DUB function XREF_BIBR."
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"CYLD is ubiquitinated at K338 and K530 by the E3 ligase mind bomb homolog 2 (MIB2), which leads to CYLD proteasomal degradation and NF-κB activation [55]."
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"Together, these observations demonstrate that IKKepsilon mediated phosphorylation of CYLD at Ser418 inhibits CYLD deubiquitinase activity."
19481526
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"These results demonstrate that phosphorylation of CYLD at Ser418 suppresses CYLD activity, resulting in increased NF-kappaB transcriptional activation."
19481526
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"CYLD knockdown by using siRNA- CYLD increased PAI-1 mRNA expression in WT MEF cells, whereas overexpression of WT CYLD attenuated PAI-1 mRNA expression in Cyld −/− MEF cells ( Figure S5 A)."
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"In line with the activation of TBK1, treatment of human primary monocytes with the combination of CXCL4 and the TLR8 ligand ORN8L induced a strong increase in CYLD phosphorylation (Fig. 1A), which is the downstream of TBK1 [10, 11]; and TBK1/IKKε can inhibit CYLD deubiquitinase activity by phosphorylation at serine 418 [11–13] (Fig. 1B)."
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"What’s more, we found that KLHL21 markedly increased the expression of CYLD in BC cells, while shKLHL21 decreased CYLD."
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"However, constitutive phosphorylation of CYLD by IKK inactivates CYLD in HTLV-1-induced leukemia to promote heightened NF-kappaB activation."
22435550
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"As IKK mediated phosphorylation of CYLD has been reported to negatively regulate CYLD enzymatic activity [XREF_BIBR], we further explored whether IKK is also involved in regulating the degradation of CYLD by SCF beta-TRCP."
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"Phosphorylation of CYLD at S418 by NF-κB signaling impairs CYLD catalytic activity enhancing TRAF2 and TRAF6 degradation (29, 30)."
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"Interestingly, recent findings also suggest that OTULIN deficiency results in spontaneous inhibitory phosphorylation of CYLD, thereby limiting CYLD activity, which can be rescued by LUBAC inhibition [XREF_BIBR]."
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"These results indicate that loss-of-function of CYLD in ECs could trigger monocyte adhesion in age-related low-grade inflammation and subsequent monocyte migration into the intima.To examine the invol[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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