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USP8 deubiquitinates ITCH. 2 / 3

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"USP8 might also modulate the stability of cFLIP L and cFLIP s indirectly by deubiquitinating Itch [90] ."

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"USP8 and USP9X deubiquitinate ITCH to induce ubiquitination and degradation of the anti-apoptotic protein c-FLIP, leading to apoptosis in glioblastoma [XREF_BIBR], or to anoikis in pancreatic ductal adenocarcinoma [XREF_BIBR]."

27203743

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USP8 deubiquitinates ITCH. 2 / 3

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