IndraLab

Statements

USP49 activates MSX1. 3 / 3
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"Thus, PAX9 and MSX1 ubiquitination was elevated in USP49 KO-hDPSCs, indicating that the loss of USP49 promotes PAX9 and MSX1 protein degradation."
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"USP49 promotes the odontogenic differentiation of hDPSCs by stabilizing PAX9 and MSX1."
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"Similarly, in HEK293 cells, we observed a USP49-mediated increase in the expression of Myc-PAX9 and Flag-MSX1 (Supplementary Fig. S3C, D), whereas USP49CA had no such effect (Supplementary Fig. S3E, F), suggesting that USP49 increases PAX9 and MSX1 protein levels.Additionally, the reduced expression of endogenous PAX9 and MSX1 proteins caused by sgRNA or shRNA targeting USP49 was rescued when hDPSCs were reconstituted with USP49 (Fig. 2F, lanes 4 and 7)."
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