IndraLab

Statements

STIM1 binds CACNA1C. 3 / 5
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"Recent evidence suggests that Homer proteins also play an important role in store operated calcium entry (SOCE), mediated by STIM and Orai proteins: Homer1b/c mediated the interactions between stromal interaction molecule 1 (STIM1) and Cav1.2 channels and between Orai1 and TRPC channels, and downregulation of Homer1b/c partially inhibited SOCE (Dionisio et al., 2015; Jia et al., 2017)."
34916418
reach
"XREF_BIBR - XREF_BIBR Due to its proximity, Arg1906Gln could alter STIM1 binding to CACNA1C, preventing the internalization of the channel, leading to an increased number of channels on the membrane, and a gain-of-function in Ca v 1.2 currents."
23677916
sparser
"STIM1-CaV1.2 interaction via the SOAR domain was demonstrated by co-immunoprecipitation of STIM1, while high-resolution imaging of ER-PM junctions revealed co-localization of STIM1/SOAR and CaV1.2 upon store depletion."
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