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STIM1 binds CACNA1C. 2 / 4

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"XREF_BIBR - XREF_BIBR Due to its proximity, Arg1906Gln could alter STIM1 binding to CACNA1C, preventing the internalization of the channel, leading to an increased number of channels on the membrane, and a gain-of-function in Ca v 1.2 currents."

23677916

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sparser

"STIM1-CaV1.2 interaction via the SOAR domain was demonstrated by co-immunoprecipitation of STIM1, while high-resolution imaging of ER-PM junctions revealed co-localization of STIM1/SOAR and CaV1.2 upon store depletion."

23568369

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STIM1 binds CACNA1C. 2 / 4

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