IndraLab

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USP18 activates cell growth. 7 / 8
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"Another study showed that USP18 expression was increased in malignant versus normal lung tissue, and loss of USP18 expression decreased lung cancer cell growth and increased apoptosis in these cancer [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP18 promotes PC cell growth by facilitating cell cycle progression."
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"USP18 promotes PC cell growth in vitro and in vivo."
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"To further understand the mechanism by which USP18 contributes to PC cell growth, we investigated the effects of USP18 knockdown on the cell cycle and apoptosis."
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"Likewise, engineered loss of USP18 expression decreased lung cancer cell growth and increased apoptosis in these cancer cells [XREF_BIBR and LM Mustachio personal communication]."
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"Consonant with our observation of enhanced cell proliferation of HEK293 and M15 cells upon exogenous Usp18 expression, a similar promotion of cellular growth by Usp18 has recently been reported in an acute promyelocytic leukemic cell lines [XREF_BIBR]."
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"Subsequently, we demonstrated that knockdown of USP18 inhibited HCC cell growth and caused cell-cycle arrest and early apoptosis."
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