IndraLab

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Ebselen inhibits NLRP3. 3 / 3
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"It was found that ebselen, a putative ONOO - scavenger, failed to decrease formation and activation of NLRP3 inflammasomes in podocytes treated with Hcys, suggesting ONOO - may not play a critical redox role in this particular pathological process in podocytes."
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"Numerous chemically distinct antioxidants (including ebselen, PDTC, MitoTEMPO and others) have been shown to inhibit NLRP3 activation [ 5 • , 85 ]."
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"NLRP3 activation can be inhibited by ebselen, a glutathione peroxidase mimetic that restores voltage-gated potassium channel function [113], and by pyrrolidine dithiocarbamate [112] which activates the NRF2 pathway."
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