IndraLab

Statements

BAP1 inhibits cell cycle. 8 / 8
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"All of these results further confirmed that BAP1 suppressed ICC cell proliferation, cell cycle progression, and invasion via inhibiting ERK1/2 and JNK/c-Jun signaling pathways."
30305612
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"Interestingly, there was no substantial difference in cell viability, BrdU incorporation or cell cycle profile between BAP1 deficient and control cells after stable expression of the shRNA constructs for at least 14days, indicating that the initial cell cycle inhibition caused by BAP1 depletion was transient."
23915344
eidos
"These results indicated that BAP1 suppressed ICC cell proliferation , cell cycle progression , and invasion via inhibiting ERK1 / 2 and JNK / c-Jun signaling pathways ."
30305612
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"XREF_BIBR reported that BAP1 overexpression in the BAP1-null NCI-H226 human non-small-cell lung cancer cell line suppressed growth in DUB activity- and nuclear localization dependent manners by accelerating the cell cycle G1/S transition and inducing cell death."
26419610
eidos
"All of these results further confirmed that BAP1 suppressed ICC cell proliferation , cell cycle progression , and invasion via inhibiting ERK1 / 2 and JNK / c-Jun signaling pathways ."
30305612
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"For example, while re-expression of BAP1 in BAP1-null H226 cells retarded cell cycle progression leading to an accumulation of cells in the S phase , depletion of BAP1 in some BAP1-proficient cells led to reduced cell proliferation with delayed G1-to-S progression ."
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"These results indicated that BAP1 suppressed ICC cell proliferation, cell cycle progression, and invasion via inhibiting ERK1/2 and JNK/c-Jun signaling pathways.To further validate these findings, we used inhibitors of the ERK1/2 pathway (U0126) and JNK/c-Jun pathway (SP600125) in RBE-shBAP1 cells."
30305612
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"Silencing BAP1 could cause retarded cell proliferation in multiple mesothelioma cell lines through arresting S-phase of cell cycle, which was remitted by reintroducing BAP1 [13] ."
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