IndraLab
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"We detected significant interactions between INHBA from cluster 5 and ACVR1 in cluster 2, coupled with a depletion in NOTCH1 signaling, both pathways known to be involved in regulating senescence ( xref and xref ). xref , xref Cluster 2 PMS iNSCs showed enrichment in senescence terms (e.g., IFN signaling and extracellular matrix [ECM]) and a depletion in differentiation and DNA transcription, known to be regulated by NOTCH signaling ( xref ). xref Clusters 4, 6, and 7 exhibited enrichment of inflammatory-associated terms and depletion in terms associated with NSC maintenance in PMS iNSCs ( xref )."