IndraLab

Statements

BAP1 binds SETD2. 11 / 11
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"Across clear cell- and papillary-associated RCC subtypes in TCGA cohort, worse survival was associated with SETD2 or BAP1 mutation, with their related gene transcriptional signatures involving greater numbers of RCC cases and also being predictive of worse outcome ( xref , xref )."
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"We and others have reported the associations of PBRM1 , SETD2 , BAP1 , and KDM5C mutations with advanced stage, grade, and tumor invasiveness [ xref , xref ], and discovered that SETD2 and BAP1 mutations are associated with lower cancer-specific survival rates [ xref , xref ]."
25124064
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"BAP1 and SETD2 mutations (6–12%) are associated with worse CSS, suggesting their roles in disease progression."
23620406
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"Furthermore, PBRM1 mutations have been found to confer a slight increase of death risk, while SETD2 or BAP1 mutations were associated with serious death risks in ccRCC patients [ xref – xref ]."
27764136
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"Similarly, a study of 609 patients with ccRCC from two distinct cohorts revealed that mutations of 3p21 epigenetic regulators BAP1 and SETD2 were associated with worse cancer-specific survival (CSS), suggesting that they play key roles in disease progression[ xref ]."
25873528
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"In pleural and peritoneal mesothelioma, co-occurring alterations occurred on the same chromosome or in close proximity for PBRM1–BAP1 (both 3p21) and SETD2–BAP1 (both 3p21), which was observed in the TCGA cohort but not in the recent publication by Zauderer and colleagues [ xref ]."
36138075
reach
"The association between VHL, PBRM1, BAP1, SETD2 AND KDM5C mutation status and overall survival was evaluated in 167 patients with metastatic ccRCC who underwent genomic sequencing of their primary tumor."
31313716
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"Here, we focus on the impact of individual mutations of PBRM1 , BAP1 , and SETD2 on cancer specific survival in an expanded version of our original cohort (3 additional patients and several more months of followup and events) and further demonstrate the association of BAP1 and SETD2 mutations with worse cancer specific survival (the TCGA cohort n=421), providing a molecular link between gene mutations and cancer specific outcomes in ccRCC."
23620406
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"BAP1 and SETD2 mutations are associated with worse cancer specific survival and likely take place during the disease progression phase."
23620406
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"Mutations in other genes like SETD2 and BAP1 which have been associated with inferior clinical outcomes in other studies were not found to be statistically significant in our analysis after adjustment."
29132830
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"Our results showed that CGN expression was positively associated with tumor suppressors BAP1 ( xref ) and SETD2 ( xref )."
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