IndraLab
Statements
Nitric oxide inhibits IRF3. 2 / 2
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2
reach
"As previously reported, Catalpalactone can inhibit the NO synthase (iNOS) expression and the production of NO, IL6 and tumor necrosis factor-α in the lipopolysaccharide-induced macrophage, and regulate the anti-inflammatory signaling, such as inhibiting STAT-1, IFN-β and IRF3 activation, to play a cytoprotecting role [21]."
reach
"Consistent with our hypothesis that dsRNA mediated induction of nitric oxide limits initiation of HSV-1 replication, inhibition of iNOS with either AMG or L-NIL partially (XREF_FIG) or fully (XREF_FIG) restored initiation of HSV-1 replication in WT or IRF3 -/- 9 -/- MEFs, respectively."