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Statements


KCNH2 activates LQTS type 2. 6 / 6
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"Mutations in hERG (also known as KCNH2), cause LQTS type 2 (LQT2) because of impaired function of the pore forming alpha-subunit of the voltage gated K v 11.1 channel, which is a key player of repolarization in cardiac cells."

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"LQTS type 2 (LQT2) is caused by mutations in KCNH2, which encodes the potassium channel hERG."

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"Mutations in HERG, located on chromosome 7q35-q36, cause LQTS type 2 (LQT2) and represent 45% of the known LQTS defects."

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"LQTS type 2 (LQT2) is caused by mutations in HERG XREF_BIBR."

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"LQTS type 2 (LQTS2) is caused by mutations in the KCNH2 gene, leading to a reduction of the rapidly activating delayed rectifier K+ current and loss of human ether-a-go-go-related gene (hERG) channel function by different mechanisms."

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"LQTS type 2 (LQTS2) is caused by mutations in the KCNH2 gene, leading to a reduction of the rapidly activating delayed rectifier K + current and loss of human ether-A -go-go-related gene (hERG) channe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"