IndraLab

Statements

KCNH2 activates LQTS type 2. 5 / 5
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"LQTS type 2 (LQT2) is caused by mutations in KCNH2, which encodes the potassium channel hERG."
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"Mutations in hERG (also known as KCNH2), cause LQTS type 2 (LQT2) because of impaired function of the pore forming alpha-subunit of the voltage gated K v 11.1 channel, which is a key player of repolarization in cardiac cells."
28235848
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"LQTS type 2 (LQTS2) is caused by mutations in the KCNH2 gene, leading to a reduction of the rapidly activating delayed rectifier K + current and loss of human ether-A -go-go-related gene (hERG) channe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19668779
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"LQTS type 2 (LQT2) is caused by mutations in HERG XREF_BIBR."
27761169
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"Mutations in HERG, located on chromosome 7q35-q36, cause LQTS type 2 (LQT2) and represent 45% of the known LQTS defects."
15242738