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USP8 increases the amount of glutathione. 3 / 3
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"We also found that depletion of USP8 increased lipid ROS levels and ferrous iron levels, while decreased the GSH levels in LM3 and HepG2 cells (Fig. 5I–K)."
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"Only USP8 WT, but not the C786A mutant, enhanced cystine uptake and GSH levels of HCC cells, while decreasing lipid ROS levels and cell sensitivity to RSL3 treatment."
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"Consistently, knockout of USP8 decreased cystine uptake, GSH level, and increased ferrous iron level and lipid ROS (Figure 3J–M)."
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