IndraLab

Statements

CACNA1C binds CACNA1G and NR2F2. 4 / 4
| 4
sparser
"Converging evidence from ENCODE ChIP-seq data and chromatin immunoprecipitation (ChIP)-qPCR results indicate that COUP-TFII interacts with CACNA1G and CACNA1C and not NKX2.5 ( xref C), implicating a role for COUP-TFII in the direct regulation of CACNA1G and CACNA1C gene expression and the functional changes observed in atrial-like hiPSC-CM calcium handling."
29731429
sparser
"Collectively, these data indicate that COUP-TFII may bind to CACNA1G and CACNA1C , thereby regulating their gene expression and modulating calcium handling in atrial-like hiPSC-CMs."
29731429
sparser
"Additionally, the genomic locations where COUP-TFII binds to CACNA1G and CACNA1C in human atrial cells and CMs are sensitive to DNase treatment, indicating that they are accessible for transcriptional regulation and are also highly conserved across species ( xref A and S2B)."
29731429
sparser
"COUP-TFII binding to the promoters of CACNA1G ( xref H) and CACNA1C ( xref I) was significantly increased in RA versus CT hiPSCs."
29731429