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Curcumin inhibits IKBKB. 12 / 17
3 | 12
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"The inhibition of DeltaTLR4 induced NF-kappaB activation by curcumin may be due to the inhibition of IKKbeta by curcumin; thus, this inhibition may not be a specific readout for the inhibition of liga[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16678799
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"Our observation is in line with the recent studies showing that Curcumin, an antioxidant and anti-inflammatory substance derived from the East Indian plant Curcuma longa, inhibits IKKbeta activity and suppresses cell proliferation as a single agent or in combination and cisplatin in HNSCC [XREF_BIBR - XREF_BIBR]."
26895469
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"Our data indicated that there is a reduced expression of IKKalpha and IKKbeta in tumor of mice treated with curcumin with respect to controls, indicating that curcumin inhibits NF-kappaB activation through suppression of IKK (XREF_FIG)."
24324975
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"Curcumin can interact with the sulfhydryl group of cysteine in the activation loop of IKKbeta, thereby inhibiting the kinase activity of IKKbeta [22]."
20939996
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"Curcumin with alpha,beta-unsaturated carbonyl group can react with SH group in cysteine in the activation loop of IKKbeta, and thereby can inhibit the kinase activity of IKKbeta."
16678799
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"First, curcumin prevents activation of IKKb (Cohen, Veena, Srivatsan, & Wang, 2009)."
34541720
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"Curcumin (10 muM) markedly inhibited IKK1 and IKK2 activity induced by LPS, whereas tetrahydrocurcumin (4H), hexahydrocurcumin (6H), and octahydrocurcumin (8H) showed a less inhibitory effect at the s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11077049
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"Curcumin, the yellow pigment derived from Curcuma longa, inhibited IKKalpha, IKKbeta and NIK, indicating its strong potential to block NF-kappaB-mediated cytokine release and the innate immune response."
15927892
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"Inhibition of IKKbeta by curcumin therefore results in reduction in NFkB occupied sites in chromatin leading to a decrease in NFkB mediated transcription."
20937593
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"Additionally, consumption of curcumin reduced activity of IKKb in a study of patients with head and neck cancer and this was associated with a decrease in the expression of IL-8, TNF-alpha, and IFN-g [XREF_BIBR]."
| PMC
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"Our data also showed that curcumin inhibited the expression of several important proteins regulated by NF-kappaB; in particular, we demonstrated that there is a reduced expression of IKKalpha and IKKbeta in tumor of mice treated with curcumin with respect to controls, indicating that curcumin inhibits NF-kappaB activation through suppression of IKK in MIA PaCa-2 cells."
24324975
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"Curcumin inhibited IKKbeta in the cytoplasm and nucleus, leading to reduced NFkappaB activity, with no effect on pAKT."
20937593