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KCNH1 activates HIF1A. 2 / 3
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"These results indicate that Eag1 expression induces an increase in HIF1alpha under mild hypoxia, which could reflect a shift on the threshold of the HIF-1 system."

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"Eag1 expressing cells were found to induce increased HIF-1alpha activity at lower concentrations of Co 2+ (XREF_FIG)."