IndraLab

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REST decreases the amount of KCNQ2. 4 / 4
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"We also show that expression of both KCNQ2 and KCNQ3 is repressed by the Repressor Element 1-Silencing Transcription factor (REST) and that expression of REST in neurons is sufficient to repress KCNQ2 and KCNQ3 expression, inhibiting functional expression of the M-current and resulting in hyperexcitable neurons."
20926649
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No evidence text available
20926649
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"Levels of repressor element 1-silencing transcription factor (REST), which is known to suppress Kcnq2 expression, were upregulated in response to neuropathic injury identifying the likely mechanism of Kcnq2 regulation."
21345591
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"This downregulation correlated with an increase of the mRNA and protein levels of REST, which negatively regulates Kcnq gene expression (eg, transient overexpression of REST in DRG suppressed Kcnq2 expression, reduced M current density, and produced highly excitable nociceptive neurons [32])."
21345591