IndraLab

Statements

COPS5 activates APP. 3 / 3
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"Taken together, these results suggest that COPS5 increases Abeta generation by increasing RanBP9 levels."
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"Furthermore, like RanBP9, COPS5 robustly increased Abeta generation, followed by increased soluble APP-beta (sAPP-beta) and decreased soluble-APP-alpha (sAPP-alpha) levels."
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"Consistently, JAB1 overexpression in APP/PS1 transgenic mice significantly increased amyloidogenic processing of APP, and reduced spinophilin (the marker of dendritic spines) in both the cortex and the hippocampus, leading to significant defects in learning and memory skills (Wang et al. 2015)."
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