IndraLab

Statements


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"The decreased activation of RelA by calcitriol was confirmed by decreased release of RelA inducible molecules, including IL-5, IL-6 and IL-8, by HBSMCs upon calcitriol treatment."

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"Calcitriol suppresses activation of the p65 subunit of the NF-κB complex in colon cancer cells, thereby preventing binding of NF-κB to DNA [115,116]."

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"1,25-dihydroxyvitamin D inhibits NF-κB p65 activation and directly controls the inflammatory cytokines that rely on NF-κB activity in macrophages (12, 27, 67)."

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"Calcitriol attenuated BLM induced elevation of nuclear NF-kappaB p65 in the lungs."

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"These data show that calcitriol prevents TNF-alpha induced increase in importin alpha3 and RelA through a process mediated by the VDR."

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"Calcitriol treatment significantly attenuated the increase of pNF-kappaB p65 after seawater administration (P < 0.001 versus seawater group)."

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"However, addition of 100 nm calcitriol reduces p65 nuclear localization in Mecp2 knock-down neurons without affecting the control neurons (XREF_FIG), indicating that vitamin D supplementation can reduce aberrant NF-kappaB signaling in Mecp2 deficient cortical neurons in vitro."