IndraLab

Statements

INHBA binds ACVR1B. 11 / 15
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"Considering the significance of the INHBA-ACVR1B and SEMA3E-PLXND1 signaling pathways in the interaction between EpiH and myeloid or endothelial cells, COMMOT software was utilized to infer the spatial signaling directionality of these two pathways. xref illustrates the INHBA-ACVR1B signaling pathway, and xref depicts the SEMA3E-PLXND1 signaling pathway."
40103807
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"Cell viability, cell apoptosis assays, and in vivo subcutaneous xenograft experiments have confirmed that INHBA-ACVR1B influences the process of tumor cell apoptosis."
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"Moreover, the connection between CX3CR1 + macrophages and tumor cells via INHBA-ACVR1B regulates tumor cell apoptosis."
38658971
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"TAM subtypes interact with different PitNET lineages; CX3CR1 + TAMs interact with NR5A1 + tumor cells through the INHBA-ACVR1B axis, promoting tumor cell apoptosis."
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"The heat map ( xref C and xref ) indicates 18 interactions enriched in FGFRL1-KD xenografts, including growth and differentiation factors with their respective ligands, including the pairs SEMA4F–NRP2, EFNB3–EPHB3, FGF2–FGFR3 or GPC4, EGF–EGFR, VEGFC–KDR or FLT4, and INHBA–ACVR1B3."
35053442
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"Furthermore, the expression of anti-tumorigenic genes (ERG2, ERG3, and BTG2) was promoted by the interaction between CX3CR1 + macrophages and NR5A1 + tumor cells through the ligand-receptor INHBA-ACVR1B pair [ xref , xref ]."
38658971
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"The identified ligand-receptor pairs, such as INHBA-ACVR1B and INHBA-ACVR2A/B, further emphasize the functional cross-talk between epithelial and myeloid cells, potentially affecting cellular proliferation and signaling cascades."
40103807
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"The INHBA-ACVR1B axis promotes tumor cell apoptosis."
38658971
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"INHBA-ACVR1B was found to be the top-ranked ligand-receptor pair among CX3CR1 + macrophages and NR5A1 + tumor cells interaction."
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"Notably, CX3CR1 + macrophages enriched NR5A1 + tumor cells and INHBA-ACVR1B were locationalized closely in the spatial transcriptome of SF1 lineage tissue (Fig.  xref B–D and Additional file xref : Fig. S10A)."
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"Consequently, these results propose that CX3CR1 + macrophages may trigger apoptosis in tumor cells through the INHBA-ACVR1B axis."
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