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SNAI1 binds OTUD4. 11 / 11
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"Moreover, purified GST-OTUD4 could interact with recombinant His-Snail1 in vitro , indicating a direct interaction between OTUD4 and Snail1 ( Fig. 2 D)."
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"To further identify the region in Snail1 that associates with OTUD4, we generated two deletion mutants of Snail1 [ 21 ]: the N-terminal Snail1 [M1, amino acids (aa) 1–153], which contains the SNAG dom[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, the interaction between OTUD4 and Snail1 was confirmed by immunofluorescence staining showing the co-localization of OTUD4 with Snail1 in the nucleus of MDA-MB-231 cells ( Fig. 2 F)."
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"Overall, our study establishes the OTUD4‐Snail1 axis as an important regulatory mechanism of BC metastasis and provides a rationale for potential therapeutic interventions in the treatment of TNBC."
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"The interaction of OTUD4 and Snail1 prompted us to examine a potential role for OTUD4 in the regulation of Snail1 stability in TNBC."
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"These results expanded our knowledge on the metastasis-promoting function of OTUD4 and provided preclinical evidence that targeting OTUD4-Snail1 axis might be a potential therapeutic strategy to conqu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, the interaction between OTUD4 and Snail1 was confirmed by immunofluorescence staining showing the co-localization of OTUD4 with Snail1 in the nucleus of MDA-MB-231 cells ( Fig. 2 F)."
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"The interaction of OTUD4 and Snail1 prompted us to examine a potential role for OTUD4 in the regulation of Snail1 stability in TNBC."
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"We next confirmed the endogenous OTUD4-Snail1 interaction by co-immunoprecipitation assay in MDA-MB-231 cells ( Fig. 2 B and C)."
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"To further examine the clinical relevance of the OTUD4-Snail1 axis in human TNBC tissues, we performed IHC analysis of 40 human TNBC specimens."
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