IndraLab

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PPP2 inhibits HCN4. 8 / 8
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"We found that PP2 can inhibit HCN4 currents by negatively shifting the voltage dependence of channel activation, decreasing the whole cell channel conductance, and slowing activation and deactivation kinetics."
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"Finally, in human embryonic kidney 293 cells overexpressing recombinant human HCN4 channels, PP2 reversed the enhancement of HCN4 channels by isoproterenol and inhibited 573x, a cyclic adenosine momophosphate-insensitive human HCN4 mutant."
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"In human embryonic kidney 293 cells overexpressing recombinant human HCN4 channels, PP2 reversed isoproterenol stimulation of HCN4 and inhibited HCN4-573x, a cAMP-insensitive human HCN4 mutant."
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"To confirm this conclusion, we needed to provide direct evidence for a well established ISO stimulation of HCN4 that is inhibited by PP2."
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"PP2 also slowed HCN4 activation kinetics regardless of ISO."
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"Our previous study showed PP2 inhibition of HCN4 activity by shifting its activation curve to more negative potentials."
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"In human embryonic kidney 293 cells overexpressing recombinant human HCN4 channels, PP2 reversed isoproterenol stimulation of HCN4 and inhibited HCN4-573x, a cAMP insensitive human HCN4 mutant."
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"PP2 inhibited HCN4 and prevented the enhancement of HCN4 by ISO."
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