IndraLab

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Scorpion toxin BmKKx2 inhibits KCNH2. 3 / 3
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"This data showed that the scorpion toxin BmKKx2 could moderately inhibit hERG channel currents in K562 cells, which is different from the nearly complete inhibition of hERG channel currents by the chemical molecules [XREF_BIBR - XREF_BIBR]."
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"Next, we investigated whether scorpion toxin BmKKx2 could inhibit the hERG channel currents in K562 cells, a chronic myelogenous leukemic cell line experessing hERG potassium channels [XREF_BIBR - XREF_BIBR]."
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"The hERG potassium channel blockage by a new 36-residue scorpion toxin BmKKx2, a potent hERG channel blocker with IC 50 of 6.7 +/-1.7 nM, enhanced the erythroid differentiation of K562 cells."
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